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Osasuna finished the match with 10 men after French midfielder Ludovic Delporte was dismissed for a wild challenge on Markel Susaeta in the 90th minute.

The defeat capped a miserable few days for the struggling club, who surrendered a 2-1 lead to Barcelona in the final 10 minutes of last weekend’s Liga match to lose 3-2 and remain rooted to the bottom of the standings.

Athletic will play Sporting Gijon in the last eight after Jorge Garcia’s header in added time sent them through at the expense of Real Valladolid.

In the other three quarters, Espanyol face city rivals Barcelona, Mallorca take on Real Betis and holders Valencia play 2007 winners Sevilla.

Gabilondo opened the scoring on five minutes, controlling an attempted clearance and curling the ball over Ricardo Lopez.

They went two up when a low shot from striker Ion Velez skewed off Josetxo and over the stranded Osasuna goalkeeper into the net.

The visitors had a chance to get back into the match when Gabilondo fouled Javier Portillo in the area with around half an hour left but the former Real Madrid striker had his penalty well saved by Athletic keeper Gorka Iraizoz.

Premier League Manchester United v Wigan Athletic live streaming and Highlights

The win against Chelsea was very important. After watching Liverpool . we needed to take advantage and get the win.

"We've done that now so come Saturday, if we do our job right and win our two games, then we'll be top."

United manager Sir Alex Ferguson is expected to be without influential defender Rio Ferdinand once again due to back trouble.

Ferdinand has been suffering spasms and was forced to miss his side's win over Chelsea before being sent for further scans on the problem.

United are still awaiting the results and Ferguson admits his absence is a big blow, although he has been full of praise for the England international's replacement at the heart of United's defence, Jonny Evans.

Evans, who is just 21, appears to be a star in the making and has deputised without putting a foot wrong.

Ferguson said: "He's been marvellous. For a young boy, 21 only a week ago, he was absolutely superb (against Chelsea).

"His reading of the game, his use of the ball, he was a giant like many of our players. I was very pleased for the boy."

Wigan manager Steve Bruce takes his in-form side to Old Trafford on the back of an incredible run of six wins in the last seven league games, but is more concerned with the future of Emile Heskey.

The England striker has been linked with moves to Liverpool and Aston Villa but Bruce has warned him that leaving the JJB Stadium could ruin his hopes of being involved in the 2010 World Cup in South Africa.

Former United centre-half Bruce said: "Emile knows that we play to his strengths and that has helped him get himself back into the England team.

"It's no secret that his return to the international scene is a result of what he has done for us.